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They were then transferred to placebo for 18, 10 and 2 weeks respectively.(6) In some patients, the switch to placebo was accompanied by withdrawal reactions.The incidence ranged from 43% in patients who had been taking a benzodiazepine for more than a year before entering the study to only 5% in the short-term users.If you subscribe to any of our print newsletters and have never activated your online account, please activate your account below for online access.
More recently, the unwanted effects of the benzodiazepines have become more obvious.
They comprise psychomotor/cognitive impairment and more serious neuropsychiatric reactions such as amnesic and aggressive episodes. Anxiety disorders are commonly found in the general population.
All treatments were given for 6 weeks and withdrawn by week 10.
By 6 weeks, the initial efficacy of diazepam had waned and by the end of the study period, patients treated with diazepam were actually worse off than those on placebo and the other treatments.
The effects generally wane beyond 28 nights and even before that time.
Whether these unequivocal short-term benefits as anxiolytic and hypnotic agents continue into the long-term remains a subject of controversy.
As with GAD, discontinuation of the benzodiazepine can be stormy with the panics reappearing often with rebound to higher levels than experienced before, and/or with withdrawal phenomena.
Direct comparisons with other effective anti-panic agents such as imipramine, an SSRI, indicates that such withdrawal after months is often an important problem requiring clinical resources for its management.
Thus, the frequent observation that many long-term benzodiazepine users claim continuing benefit cannot be taken at its face value.
One important study involved chronically anxious patients who were being treated with benzodiazepines for 6, 14 or 22 weeks.
This review will first list the benefits and risks of these drugs and then outline their uses. Acute stress reactions and anxiety symptoms as part of other psychiatric disorders or physical disorders are very commonly encountered.Tags: Adult Dating, affair dating, sex dating